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A survey of new knowledge

wallpapers News 2020-07-10

science: faecal bacteria transplantation can improve the anti PD-1 immunotherapy in patients with melanoma respond to the

core point: the intestinal flora composition of metastatic melanoma patients with ineffective anti-PD-1 treatment is changed through bacterial transplantation the immune cell infiltration gene expression profile in the intestinal tract tumor microenvironment are improved. It is suggested that the clinical application of reconstituting the immune response of the patients is promising. For information about

please refer to: https://doi.org/10.1126/science.abb5920

cells: transplantation of maternal intestinal flora can quickly restore intestinal microbiota of caesarean birth infants Oral administration of 3.5 mg of maternal flora at the time of first lactation after birth can restore the defects in composition development of intestinal flora in caesarean section infants making them similar to those delivered by vagina without any adverse effects on the health of infants. But its effectiveness safety still need long-term evaluation. For information about

please refer to: https://doi.org/10.1016/j.cell.2020.08.047

cell host microorganism: the core point of

is that quorum sensing regulates the transformation of intestinal symbiotic bacteria into pathogenic bacteria The high level of uridine in the intestine of Drosophila melanogaster can be decomposed into uracil ribose by pathogenic symbionts. The ribose derived from uridine can be used as a signal molecule to induce the expression of QS virulence genes among bacteria which makes it transform from symbiosis to pathogenicity. This indicates that it is an important trend to pay attention to the integrity of the flora the ecology among the strains in the future. For information about

please refer to: https://doi.org/10.1016/j.chom.2020.01.025

cell: intestinal flora helps host resist virus infection Intestinal Bacteroides such as the outer membrane glycolipids of Bacteroides fragilis can activate colon dendritic cells promote their secretion of IFN - β through tlr4-trif signaling pathway further regulate the expression of interferon stimulating gene (ISG) of host so as to effectively resist viral infection. These preliminary results lay a theoretical foundation for further clinical research on bacterial intervention in the treatment of viral infection. For information about

please refer to: https://doi.org/10.1016/j.cell.2020.10.047

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