Home > News > Advanced science: lncrna afap1-as1 gene silencing mediated by nanoparticles is used to reverse radiation resistance and realize combined tumor therapy

Advanced science: lncrna afap1-as1 gene silencing mediated by nanoparticles is used to reverse radiation resistance and realize combined tumor therapy

wallpapers News 2020-09-18

radiation resistance is a common clinical problem leading to poor prognosis of tumor patients. Long non coding RNA (lncrna) plays an important role in inducing tumor resistance to radiotherapy because it can regulate the expression of target genes at the transcriptional or post transcriptional level. To explore the key lncrna elucidate its mechanism of inducing radiation resistance will help to develop methods to reverse radiation resistance improve the therapeutic effect of tumor.

recently Sun Yat sen University team Xu Xiaoding team Yao Herui used tissue samples from patients with triple negative breast cancer before after recurrence to identify lncafap1-as1 plays an important role in breast cancer radiotherapy resistance with the help of high-throughput sequencing technology. Further analysis of 125 clinical samples of triple negative breast cancer patients found that the high expression of lncafap1-as1 was positively correlated with the poor prognosis of patients. Molecular mechanism studies show that lncafap1-as1 enhances the activity of Wnt / β - catenin signaling pathway by inhibiting ubiquitin degradation of β - Catenin promotes the proliferation invasion migration of triple negative breast cancer cells. Based on the fact that tumor cells can adaptively produce a large amount of glutathione (GSH) during radiotherapy the research team further constructed a reduction responsive nanocarrier system to deliver small interfering RNA (siRNA) silence the expression of lncafap1-as1. In vivo in vitro experiments confirmed that the nano delivery system can not only achieve the efficient silencing of lncafap1-as1 but also use its reductive responsiveness to consume GSH in tumor cells enhance the sensitivity of radiotherapy. This study not only reveals that lncafap1-as1 can be used as a marker to predict the radiosensitivity of triple negative breast cancer but also provides a potential therapeutic strategy for triple negative breast cancer with recurrence metastasis due to radiotherapy resistance. This study


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